2017-07-25 16:36:322025-05-10 16:57:55

locus

BSU22640

BSU_22640

outlinks

bsu

BSU22640

BSU_22640

The protein

Catalyzed reaction/ biological activity

L-serine 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan glyceraldehyde 3-phosphate H₂O (according to Swiss-Prot)

(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine --> D-glyceraldehyde 3-phosphate + H₂O + L-tryptophan (according to UniProt)

The protein

Structure

[PDB|5EY5] ([[protein|TrpA]]-[[protein|TrpB]] complex, 66% identity)

[PDB|4NEG] (from Bacillus anthracis, 60% identity)

References

Reviews

18486479, 11893063, 11163353, 7900177, 19387555, 12859215, 11395405

18486479, 11893063, 11163353, 7900177, 19387555, 12859215, 11395405, 12966138

References

Original publications

14976255, 3924737, 6436812, 2422155, 8419914, 1551827, 17507374, 21815947

14976255, 3924737, 6436812, 2422155, 8419914, 1551827, 17507374, 21815947, 31871208

The protein

Protein family

TrpB family (single member, according to UniProt)

The protein

Paralogous protein(s)

[[this]]

The protein

[SW|Cofactors]

PLP (according to UniProt)

Biological materials

Mutant

BKE22640 (Δ[[gene|trpB]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE22640 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCCAAAATCACCGTATCTGC, downstream forward: _UP4_GTATTGGAAGAAGAGGTGAA

BKK22640 (Δ[[gene|trpB]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK22640 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCCAAAATCACCGTATCTGC, downstream forward: _UP4_GTATTGGAAGAAGAGGTGAA